NanoStraw Technology

NanoStraw Transfection is Gentle, Precise and Cargo-Agnostic

The NanoStraw technology is a versatile platform technology which establishes a direct, physical connection into cells to overcome a huge challenge faced by cell/gene therapy and regenerative medicine companies globally: delivering materials into hard-to-transfect-cells in a gentle, non-perturbative manner.

Cargo delivery via NanoStraws drastically reduces the working steps, costs, technical difficulties and cell death involved in cell therapy manufacturing. By overcoming viability and manufacturing challenges plaguing traditional viral-based and electroporation-based development, NAVAN is actively innovating therapies in a broad range of indications with strategic partners.

Nanostraws are a key development over the last decade

Stewart et al, NATURE research review, Oct. 2016

Novel Mechanism of Transport Enables Best-in-Class Capabilities

Cargo-Agnostic

Capable of delivering DNA, mRNA, and proteins with high efficacy, including functionally-active proteins such as Cas9 and others.

Effectiveness of Delivery

Gentle, non-perturbative delivery is effective for virtually all primary cell types with unparalleled cell viability and recovery yield.

Published results prove adoptive efficacy in vivo of Navan transfected cells is the same as completely untreated cells.

Dosage Control

NanoStraw platform allows for precise dosage control which is unachievable with standard chemical or physical delivery.

Fully-Scalable Approach

From a small number of cells (~5), relevant for rare cell types, to delivery of 10s of Millions of cells at once in a multi-well plate.

A much larger capacity system (1 Billion+ cells) is in development now.